GPT and neoplasm: More importantly, multivariate analysis revealed that the postoperative AST/ALT ratio (hazard ratio, HR: 1.88, 95% CI: 1.18–2.99) and pre-to-postoperative dynamics of the AST/ALT ratio (HR: 3.45, 95% CI: 1.73–6.88) remained as significant prognostic factors for CSS, in addition to tumor size (HR: 4.23, 95% CI: 2.66–6.72) and pT stage (HR: 2.45, 95% CI: 1.53–3.94) (Table 2).