Moreover, PD-L1 was associated with low differentiation (OR = 1.43, 95%CI = 1.09 − 1.87, p = 0.010) and higher pN stage (OR = 1.45, 95%CI = 1.10 − 1.92, p = 0.009) but not with sex, TNM stage, vascular invasion, perineural invasion, age, or tumor size. This evidence concerns the gene CD274 and neoplasm.