Lu et al. reported that downregulated MCT2 expression in the cerebral cortex and hippocampus in an Aβ(25-35)-treated rat model of AD may be correlated with the pathologic progression of AD, and the MCT2 protein level in the APP/PS1 transgenic mice was lower than that in the WT C57BL/6J mice 66, 67. The gene discussed is APP; the disease is Alzheimer disease.