CD4 and neoplasm: As shown in Figure S1, except for the lack of apparent differences in tumor- draining lymph nodes (Figure S1A), the percentages of apoptotic overall immune cells, CD4+ T, and CD8+ T cells remarkably increased in both PBMCs and tumor-infiltrating immune cells after high-dose nano-PTX (40 mg/kg) treatment (Figure S1B-C), while the dose of 10 mg/kg was safe for the immune system (Figure S1B-C).