IL-1β, IL-12, IL-18, and CXCL9 secreted by DCs are essential for antigen presentation 8, 40, 41 and T cell chemotaxis 42; our data show that PTX and OXP but not CDDP treatment significantly increased IL-1β, IL-12, IL-18, and CXCL9 expression in the co-culture supernatant (Figure 4H-K), indicating that PTX treatment preferred the tumor cells presented by DCs in vitro. The gene discussed is IL1B; the disease is neoplasm.