SH3PXD2A and breast carcinoma: As shown in Figure 2H, while emodin itself did not affect Cortactin or Tks5 expression in breast cancer cells, PMCM from macrophages treated with EO771 conditioned medium significantly increased the expression of these two genes; moreover, upregulation of these genes was abolished if the macrophages were treated with emodin in addition to EO771 conditioned medium.