TFEB and pulmonary fibrosis: More recently, it has been reported that the overexpression of TFEB or treatment with a TFEB activator, trehalose, suppressed the levels of inflammatory cytokine and prevented lung fibrosis by attenuating lysosomal dysfunction and augmenting autophagy flux in alveolar macrophages, which was abolished by CQ, bafilomycin A1 and TFEB knockdown 95.