TGFB1 and idiopathic pulmonary fibrosis: Several studies have shown that several antioxidant agents and bioactive natural products, such as coenzyme Q 10 (CoQ10), celastrol and ligustrazin, promoted autophagy, reduced expression of TGF-β and Col-1 and protected against different chemical compounds-induced IPF through the downregulation of the PI3K/Akt/mTOR pathways in animal models 112-114.