Annexin A2 (ANXA2) was observed to alleviate lung fibrosis caused by BLM by combining with BLM and accelerating TFEB-mediated autophagy flux in vitro and in vivo, which was abolished by CQ and bafilomycin A1 in the ANXA2 genetic depletion mice and CRISPR-Cas9-engineered ANXA2 mutation lung epithelial cells 94. Here, TFEB is linked to pulmonary fibrosis.