These results demonstrated that the exosomes-contained lnc-MDK-4:2 and lnc-FAM32A-2:1 might play potential important roles in regulating biosynthesis and metabolism in the recipient cells all over the body, especially the IL17-mediated signaling and autophagy initiation regulation which contributed to host defense and pathogenesis of various autoimmune diseases. This evidence concerns the gene IL17A and autoimmune disease.