The univariate analysis indicated that pCR occurrence in patients with LARC after neoadjuvant CRT was significantly associated with gender, age, tumor location, type of chemotherapy, clinical tumor stage, clinical nodal stage, tumor-node-metastasis stage, tumor grade, post-CRT CEA level, anemia, diarrhea, urinary symptoms, dermatitis, leukopenia, radiation therapy dose, and the radiation to surgery interval (P < 0.01). This evidence concerns the gene CEACAM5 and anemia (phenotype).