CEACAM5 and neoplasm: The global sensitivity analysis demonstrated that the most sensitive variable for predicting pCR occurrence in patients with LARC after neoadjuvant CRT was post-CRT CEA levels (VSR = 1.57), followed by intervals between radiation and surgery (VSR = 1.50), types of chemotherapy (VSR = 1.45), clinical nodal stages (VSR = 1.37), and clinical tumor stages (VSR = 1.32) (Table 5).