As it can be seen, administration of exogenous gp96 promoted liver injury in both lower doses of LPS/d-Galn- and ConA-induced liver failure models, as evidenced by elevated serum ALT levels (Fig. 4c,f), obviously increased darkness of liver color (Supplementary Fig. S4c), and increased liver necrosis with the signature of loss of architecture (Fig. 4d,g). Here, HSP90B1 is linked to Hepatic failure.