HSP90B1 and Hepatic failure: In addition, currently it is difficult to totally mechanically distinguish the exact roles of gp96 and other potential DAMPs (e.g. other HSPs) released from necrotic hepatocytes in induction of the necroinflammation in liver failure, although inhibition of extracellular gp96 with its specific inhibitor was shown to largely attenuate immune hyperactivation and symptoms of liver failure in mice models.