In co-culture with NLC, the inhibition of BDNF alone or in combination with the co-inhibition of BAFF, APRIL and CXCR4 decreased NTSR2 expression of B-CLL to a level similar to that was obtained in B-CLL alone (Fig. 4a, b). Here, TNFSF13B is linked to B-cell chronic lymphocytic leukemia.