In co-culture with NLC, the inhibition of BDNF alone or in combination with the co-inhibition of BAFF, APRIL and CXCR4 decreased NTSR2 expression of B-CLL to a level similar to that was obtained in B-CLL alone (Fig. 4a, b). The gene discussed is CXCR4; the disease is B-cell chronic lymphocytic leukemia.