Indeed, nurse-like cells (NLC), which are type II macrophages differentiated in the presence of B-CLL cells4, act as tumor-associated macrophages (TAMs)5 by releasing pro-survival cytokines such as B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL), and stromal cell-derived factor 1 (SDF-1) [also called CXCL12 (C-X-C Motif Chemokine Ligand 12)]4,6,7. The gene discussed is TNFSF13B; the disease is neoplasm.