Five of these clusters are members of the aforementioned PBC-associated metaclusters; these include: (1) Cluster-9 (Metacluster-3), a subset of gamma-delta T cells expressing CXCR3; (2) Cluster-10 (Metacluster-4), a subset of CD161+CD8+ T cells expressing high levels of CD56; (3) Cluster-11 (Metacluster-4), a subset of CD161+CD8+ T cells expressing high levels of CTLA4; (4) Cluster-27 (Metacluster-4), a subset of CD161+PD1+CD8+ T cells; and (5) Cluster-177 (Metacluster-16), a subset of B cells expressing high levels of CD24 and CX3CR1. The gene discussed is CTLA4; the disease is primary biliary cholangitis.