In addition to its reliance on androgen receptor signaling from organ-confined to metastatic, castration-resistant disease12,13, other hallmarks of PCa are its multifocality14, its multiclonality15,16 and its notable inter- and intraindividual heterogeneity17–20; due to these qualities, PCa management is a major challenge, and thus, further elucidation of the unique biology of this disease is urgently needed. This evidence concerns the gene AR and posterior cortical atrophy.