The number of lymph node metastases was significantly higher in LuCaP136 + CAF1 vs. LuCaP136 + NCAF1 (p < 0.03), in LuCaP136 + CAF2 vs. LuCaP136 + NCAF2/ LuCaP136 + BPHF2/ LuCaP136 alone (each p < 0.05) and in LuCaP136 + CAF3 vs. LuCaP136 + NCAF3 (p = 0.01). This evidence concerns the gene CNOT8 and metastatic malignant neoplasm in the lymph nodes.