Hence, we analysed DPP4 activity, sDPP4 protein and levels of inflammatory markers in plasma samples from 600 subjects with T2D treated with or without sitagliptin for 12 months from the TECOS trial, a study examining the safety of sitagliptin in subjects with T2D and established cardiovascular disease30. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.