NF2 and meningioma: This approach may not work for NF2-associated meningiomas because of the (1) uncertainty in deciding which tumor is symptomatic when multiple discrete meningiomas in widespread intracranial locations are progressing simultaneously, (2) presence of large areas of confluent tumors, mimicking en plaque meningioma, and (3) radiation therapy or SRS may have greater potential to cause malignant conversion of the meningioma and surrounding tissue in the setting of an underlying genetic tumor syndrome.