CXCL8 and bacterial vaginosis: GPCR signaling encompasses a broad range of actions, but in conjunction with our pathway results implicating IL-8 and TLRs and other studies showing potential roles for GPCR in cervicovaginal health, GPCR signaling merits further study as a potential pathway affecting acquisition or maintenance of vaginal L. crispatus, CST membership, and subsequent BV status.