CD4 and neoplasm: The median nearest neighbor distance from tumor to immune cells are 2.9 um for CD16+ myeloid, 23.2 um for CD3 + CD4-CD8- T-cells, 44.5 um for CD4+ helper T-cells, 24.0 for CD8+ cytotoxic T-cells, and 56.9 μm for CD20+ B-cells, respectively (Fig. S4).