CD8A and neoplasm: In addition, Hettich et al. conducted a detailed tumor-infiltrating lymphocyte (TIL) kinetic evaluation of the tumor microenvironment after hypofractionated radiotherapy of 24 Gy in 2 fractions, observing that there was a transient increase in tumor-specific CD8+ TILs at approximately days 5–8 after radiation, while unexpectedly, suppressive Treg cells dominated around days 10–16 [80].