Regarding PCNXL2 (pecanex-like 2), namely FLJ11383|KIAA0435, a previous report suggested that it might have a certain influence on the tumorigenesis of colorectal carcinomas with high microsatellite instability [36], which may be a new breakthrough point for immunotherapy with the progress of genomics research and the maturation of protein antibody preparation technology. This evidence concerns the gene PCNX2 and colorectal carcinoma.