To directly elucidate the epistatic relationship between FOXM1 and TPX2 in HCC proliferation, we weakened the expression of TPX2 in Huh7 cells over-expressing FOXM1 (Fig. 6a) and conducted a series of EdU assays, colony formation assay, and anchorage-independent colony formation and cell survival assays. Here, FOXM1 is linked to hepatocellular carcinoma.