Consequently, we established a retrospective single-institutional database including consecutive patients with EGFR-mutated advanced NSCLC between January 2012 and June 2018, to evaluate the impact of BM status on OS, to explore the possible risk factors for developing metachronous BM during the course of first-generation EGFR-TKIs therapy, and to identify the potential candidates for PCI or the first-line Osimertinib treatment. This evidence concerns the gene EGFR and non-small cell lung carcinoma.