Therefore, this study aims to analyze the expression of cytokines and chemokines such as IL-1β, IL-6, IL-4, IL-10, TNF-α, TNFR1 (tumor necrosis fator receptor-1), IL-8, MIP-1α e eotaxin in renal biopsies from patients with DN and determine its correlation with interstitial inflammation and decreased renal function. The gene discussed is TNFRSF1A; the disease is liver dysplastic nodule.