Considering the fact that the majority (87%) of cases had advanced disease, we performed analyzes comparing patients with eGFR < 60 mL / min / 1.73m2 X patients with eGFR> 60 mL / min / 1.73m2 in DN group, as follow: IL-6 (p = 0.8129; U = 85); IL-1β (p = 0.2197; t = 1.252); IL-4 (p = 0.8329; t = 0.2128); TNFR1 (p = 0.0996; t = 1.698); IL-10 (p = 0.6553; t = 0.4507); TNF-α (p = 0.2874; t = 1.082); eotaxin (p = 0.0819; t = 1.795); IL-8 (p = 0.8882; t = 0.1417) and MIP-1α (p = 0.1166; t = 1.614). Here, CXCL8 is linked to liver dysplastic nodule.