A study with microalbuminuric DMT2 patients demonstrated the activation of innate immunity in glomeruli of patients with DMT2 and early nephropathy and suggested that improved Toll-like receptors 4 (TLR4) signaling, expressed in native renal cells, may contribute to the progression of microalbuminuric for macroalbuminuric nephropathy [20]. This evidence concerns the gene TLR4 and kidney disorder.