Previously, NLK has been reported to be involved in the regulation of several signalling pathways.21 Since NLK is up‐regulated and plays a tumorigenic part in HCC,22, 23 here we wondered whether ASMTL‐AS1 functioned in HCC by targeting NLK‐regulated tumour‐suppressive Hippo signalling. This evidence concerns the gene ASMTL and neoplasm.