Interestingly, the function of lncRNAs usually links with their subcellular fates.30 For example, lncRNA SNHG1 was retented in nucleus and competes with p53 to interact with hnRNPC.31 LncRNA CRCMSL prevents the nucleocytoplasmic shuttling of HMGB2 by directly binding to HMGB2 in the cytoplasm.32 In this study, we discovered that ASMTL‐AS1 mainly existed in the cytoplasm of HCC cells, regardless of heat treatment. This evidence concerns the gene MAP2K6 and hepatocellular carcinoma.