To further make sure the role of ASMTL‐AS1/miR‐342‐3p/NLK/YAP axis in residual HCC after insufficient RFA, we analysed the expression of relevant genes in the serum and serum exosomes (SEs) from HCC patients including those with insufficient RFA. The gene discussed is ASMTL; the disease is hepatocellular carcinoma.