Identified from screening a small library of compounds by in vitro DNA-binding assays, p53R3 can inhibit the proliferation of cancer cells expressing mutp53 by inducing the expression of p53 target genes, including p21, PUMA, and BAX, to induce cell cycle arrest and apoptosis of cancer cells (Weinmann et al., 2008). The gene discussed is TP53; the disease is cancer.