HDAC6 and cancer: Since the interaction of mutp53 with the HDAC6/HSP90 chaperone complex is critical for mutp53 stabilization in cancer cells, disruption of the HDAC6/HSP90 complex by inhibitors of HSP90 or HDAC6 has been shown to be a promising strategy to induce mutp53 degradation (Peng et al., 2001; Li et al., 2011a, b).