Identified from a cell-based luciferase-reporter screen, Chetomin specifically reactivates R175H mutp53 to the wild-type p53 conformation through increasing its binding capacity with DNAJB1 (Hsp40), which selectively inhibits the growth of cancer cells with R175H but not R273H mutp53 (Hiraki et al., 2015). Here, TP53 is linked to cancer.