EGFR and neoplasm: For instance, mutp53 upregulates EGFR/integrin recycling and PDGFRβ to promote tumor metastasis, and thus inhibition of EGFR by cetuximab or inhibition of PDGFRβ by imatinib blocks cancer metastasis (Muller et al., 2009; Weissmueller et al., 2014).