Notably, a recent study analyzed p53 mutations in 10225 samples from 32 cancers from The Cancer Genome Atlas (TCGA) and reported that >91% of p53-mutant cancers exhibit loss of the second allele of p53 by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity (Donehower et al., 2019). Here, TP53 is linked to cancer.