Inhibition of critical enzymes in the mevalonate pathway, such as inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by Statins, geranylgeranyl transferase 1 (GGTase 1) by GGTI-298, and farnesyl diphosphate synthase (FDPS) by zoledronic acid, was shown to destabilize mutp53 and inhibit the growth and invasion of cancer cells expressing mutp53 (Freed-Pastor et al., 2012; Ingallina et al., 2018). Here, FDPS is linked to cancer.