Furthermore, mutp53 (e.g. R175H) downregulates miR-223 expression in cancer cells to induce chemoresistance through binding to miR-223 promoter to reduce its expression via the transcriptional repressor ZEB-1, which in turn induces Stathmin-1, an oncoprotein that confers chemoresistance partially through regulating microtubule dynamics (Masciarelli et al., 2014). This evidence concerns the gene ZEB1 and cancer.