Through transcriptionally regulating these genes, p53 plays critical roles in many important biological processes, including apoptosis, cell cycle arrest, senescence, DNA repair, cell metabolism, and antioxidant defense, which contribute to p53’s function in tumor suppression (Levine et al., 2006; Muller and Vousden, 2013; Levine, 2019). Here, TP53 is linked to neoplasm.