In addition, R249S mutp53 interacts with Pin1 after being phosphorylated by CDK4/cyclin D1 at the S249 residue and then is imported into the nucleus to stabilize c-Myc protein, resulting in the transcriptional activation of Myc target genes to promote proliferation of hepatocellular carcinoma cells (Liao et al., 2017; Wang et al., 2019). The gene discussed is MYC; the disease is hepatocellular carcinoma.