WFA treatment significantly reduced the circulating levels of Ang II in the tumor bearing mice compared to the tumor-bearing vehicle-treated group (WFA 2 mg/kg: 2.15 ± 0.015 ng/ml, p < 0.01; WFA 4 mg/kg: 2.07 ± 0.08 ng/ml, p < 0.01) (Fig 5A). This evidence concerns the gene AGT and neoplasm.