Tumor-induced cardiac remodeling involves increased levels of pro-inflammatory cytokines, such as IL-1β, IL-6, and IL-8, as well as ventricular thinning and decreased troponin-I levels, as shown in Figs 2 and 5, resulting in dysfunctional contraction and relaxation of the heart (Fig 2). The gene discussed is CXCL8; the disease is neoplasm.