HLA-C and neoplasm: Further, we hypothesized that xenografting of ovarian cancer into female mice would induce a cachectic phenotype in cardiac muscle through AT1R. Ang II released from tumor induces shift in MHC isoforms from a predominantly adult α-MHC state to one that is primarily embryonic β-MHC in the tumor-bearing vehicle-treated group compared to the tumor-free vehicle-treated group and caused cardiac cachexia.