As Table 1 shows, blood glucose, as well as the levels of ALP, CTX-1, TRACP 5b, osteocalcin, PINP, and RANKL in serum increased in the diabetic group (diabetes vs. control, p < 0.01) and the RUNX 2—as well as OPG levels decreased (diabetes vs. control, p < 0.01). The gene discussed is TNFSF11; the disease is diabetes mellitus.