We did not detect statistically significant interactions between coffee consumption and five SNPs related to type 2 diabetes (CDKAL1 rs7756992, CDKN2A/B rs10811661, KCNJ11 rs5215, KCNQ1 rs163184, and PEPD rs3786897) in the association between coffee and the risk of type 2 diabetes. This evidence concerns the gene CDKAL1 and type 2 diabetes mellitus.