RPS6KB1 and Alzheimer disease: The brains of patients with advanced Alzheimer’s disease (AD) showed a systematic disorder of protein synthesis that is dominated by increased levels of phosphorylated (p) proteins, including p-mTOR (hyperactivated), p-p70S6K, p-4E-BP1 (inactivated), and p-eIF4E (likely involved in the increased activity) [153,154,155].