NFKB1 and neoplasm: Moreover, DGKα is involved in inflammation in tumor cells by positively regulating tumor necrosis factor α (TNFα)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation via a PKCζ-mediated Ser311 phosphorylation of the NF-κB subunit p65/RelA [64].