DGKζ is a negative regulator of cell cycle progression in C2C12 mouse myoblasts: DGKζ overexpression blocked cells at the G1 phase of the cell cycle via its interaction with the Retinoblastoma protein (pRb) which is a tumor suppressor and a cell cycle regulator, and DGKζ downregulation increased the number of cells at both S and G2/M phases of the cell cycle [97]. The gene discussed is DGKZ; the disease is neoplasm.