Concerning the epoxides metabolized via CYP450, a study showed MC38 colorectal cancer cell line implants in mice to grow less rapidly when the animals were fed with a ω-3 PUFA-enriched diet; furthermore, the CYP450-metabolized ω-3 derivative epoxydocosapentaenoic acids (EDPs) were found to be responsible for tumor growth suppression in vivo, with the concomitant reduction of pro-oncogenic c-Myc, Axin2, and C-jun genes in tumor tissues [124] (Figure 3c). This evidence concerns the gene JUN and neoplasm.