FFAR4 and colorectal carcinoma: During AOM/DSS-induced colorectal carcinogenesis, animals fed with a ω-3-enriched diet showed tumors reduced in size, number, and activation of the Hippo pathway compared to control diet-fed mice [142], suggesting that GPR120 may mediate the antitumoral effect exerted by ω-3 PUFAs in CRC.