As an example, Wu and colleagues found that the expression of FFAR4, the gene encoding for GPR120, is upregulated in human CRC tissues compared to adjacent noncancerous areas [139] and that the expression of the receptor increases as the clinical stage of cancer advanced, with 100% of stage III histological grade CRCs expressing high levels of GPR120. The gene discussed is FFAR4; the disease is colorectal carcinoma.