IL1β participates in the activation of Nuclear Factor Kappa-light-chain-enhancer of activated B cells (NF-κB)-driver molecular machinery [61] and, for this reason, was classified as pivotal signal molecule contributing to CRC pathogenesis in both preclinical studies, exploiting either the AOM/DSS [62] or the genetic models of CRC [52] and human samples [63], where polymorphisms in its gene and receptors are associated with this disease [64]. This evidence concerns the gene NFKB1 and colorectal carcinoma.