TGFB1 and colorectal carcinoma: Its relationship with CRC relies on the discovery of the high rate of CRC-associated mutations in genes encoding for the TGFβ signaling-related proteins [57] that lead to molecular dysfunctions, rendering the TGFβ a growth stimulator, causing cancer progression and malignant transformation [58] by programming the metastasization process in locally advanced CRC [59,60].