Two SNARE protein family members, vesicular associated membrane protein 7 (VAMP7) and Synaptobrevin homolog YKT6 (YKT6), have been identified to play a major role in exosome release, specifically in human lung cancer cell lines, human embryonic kidney 293 cells (HEK293) and Adenocarcinomic human alveolar basal epithelial 549 cells (A549) [59,60]. The gene discussed is YKT6; the disease is lung cancer.