We also identified variants in genes that are linked to neurological syndromes, such as MECP2, CDKL5, GRIN2A, SCN1A, PCDH19, UBE3A, and SLC9A6. Developmental regression is frequently seen in patients with Rett Syndrome, Landau Kleffner Syndrome, and Christianson Syndrome. This evidence concerns the gene UBE3A and developmental and/or epileptic encephalopathy with spike-wave activation in sleep.