SOCS3 and infection: Asibi infection up-regulated the expression of SOCS3 by about 2-folds in both the early and late phase (24 hpi) of infection in HeLa cells, whilst YF-17D down-regulated SOCS3 levels at initial (3 hpi) and later phases (48 hpi) of infection but the expression was not altered between 12 hpi and 24 hpi in HeLa cells (Figure 3C).