mRNA expression of PIAS1 and PIAS4, as shown in Figure 4, from our data appears to follow a rise–dip–rise–dip pattern, characteristic of circadian rhythm movement, but empirical data to confirm whether PIAS expression in YFV or flavivirus infections is affected by the circadian-controlled genes remains to be explored. The gene discussed is PIAS4; the disease is Flavivirus Infections.