It is intriguing to note that, instead, in breast cancers, ovarian serous cystadenocarcinoma, colorectal adenocarcinoma, or skin cutaneous melanoma, active caspase 7 levels (measured by Reverse Phase Protein Array) positively correlate with numerous molecular markers of cytotoxic immune cell activation (including STAT1, Interferon type II, or granzyme genes) and immune checkpoints (including CTLA4, CD274, or PDCD1), suggesting tonic immune reactions in caspase 7 high tumors. Here, CASP7 is linked to breast cancer.