Therefore, high plasma Smad4 levels were associated with the presence of hypertension (odds ratio [OR] per 50 pg/mL Smad4 increase 1.192, 95% confidence interval [CI] 1.031 to 1.378, p = 0.018), although the odds ratio adjusted for sex, age and body mass index (BMI) did not reach the threshold of statistical significance (adjusted OR 1.255, 95% CI 0.988 to 1.594, p = 0.063). Here, SMAD4 is linked to hypertensive disorder.