Thus, increased Smad4 levels were also a risk factor for a clinical diagnosis of diabetes (OR 1.301, 95% CI 1.071 to 1.580, p = 0.008), even after adjusting for age, sex, and BMI (adjusted OR 1.344, 95% CI 1.037 to 1.741, p = 0.025). The gene discussed is SMAD4; the disease is diabetes mellitus.