In neurons, ORAI1 appears dispensable for SOCE [46], but it has been implicated in neuronal excitability [45,48], whereas ORAI2 seems to be part of a neuronal SOC (nSOC) based on TRPC6 and activated by STIM2, and its activity is impaired in mouse AD models [46]. This evidence concerns the gene ORAI2 and Alzheimer disease.