In HEK293T cells, ORAI2 was also suggested to be part of the elusive ER Ca2+ leak channel [52], therefore offering a possible link between ER and SOCE alterations found in different FAD models ranging from cell lines, fibroblasts and induced pluripotent stem cells from FAD patients [19,20,53] to neurons and astrocytes from AD mouse models [9,10,11,14,46,54]. Here, ORAI2 is linked to familial Alzheimer disease.