ORAI2 and Alzheimer disease: In conclusion, here, we showed that, in Aβ-secreting neuroglioma cells, downregulation of ORAI2 potentiates SOCE without altering the store Ca2+ content and decreases the Aβ42/Aβ40 ratio thus being an interesting tool to restore defective Ca2+ entry associated to AD [9,10,54,76], while preventing amyloid seeding, given the direct correlation of this latter with the Aβ42/Aβ40 ratio.