PKM and neoplasm: Similarly, in group-B, tumours with high PKM2 mRNA expression presented significantly lower PFS (6.7 months, 95% confidence interval (CI): 4.8–7.5 months) in comparison with those with low PKM2 mRNA expression tumours (9.1 months, 95% CI: 7.7–11.2 months; p = 0.003; Figure 1C).