Phosphate metabolism is regulated by bone-derived FGF-23 and PTH, which influence the renal production and circulating concentrations of the active metabolite of VD, 1,25-hydroxyvitamin D [1,25(OH)D], which affects bone metabolism, intestinal absorption of calcium and phosphorus, and hypertension and vascular calcification [40]. The gene discussed is PTH; the disease is Hypertension.