BRD4 and neoplasm: Various preclinical studies identified signaling pathways or key genes, such as the jumonji domain, containing proteins (JMJD3), STAT3, STAT6, BRD4, Myc, Rac2, Syk, PI3Kγ, Btk, etc. which play a crucial role in stimulating alternative activation of macrophages and promoting tumor growth in solid tumors [115,120,208,209,210,211].