Immunosuppressive microenvironment in NB is generated due to various reasons, which include (1) infiltrating immunosuppressive immune cells including macrophages, regulatory T cells and myeloid derived suppressor cells, (2) soluble factors secreted in neuroblastoma microenvironment which mediates immunosuppression like TGF beta, IL10, and galectin-1, (3) defects in antigen-presenting machinery (APM) and low levels of MHC class I molecule displayed by NB cells. The gene discussed is IL10; the disease is neuroblastoma.