M2 polarized macrophages are commonly known as tumor associated macrophages and they express M2 macrophage markers, i.e., CD163 or CD206, secrete vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP) and produces immunosuppressive cytokines, i.e., IL10, and transforming growth factor β (TGFβ) which dampens effective anti-tumor immune responses and promote tumor progression and metastasis. The gene discussed is VEGFA; the disease is neoplasm.