The administration of calnexin in glucan particles elicited calnexin-specific CD4+ T cells, and vaccinated mice demonstrated resistance to infection by Blastomyces dermatitidis, Histoplasma capsulatum, Pseudogymnoascus (Geomyces) destructans, Fonsecaea pedrosoi, and A. fumigatus [97]. This evidence concerns the gene CD4 and infection.