DDB2 and metastatic malignant neoplasm in the lymph nodes: Furthermore, downregulation of DDB2 mRNA was correlated with lymph node metastasis and poor overall survival of HNC patients with BQ-chewing habits (Table 1 and Figure 7), although the effect of DDB2 on HNC patients’ survival might be regulated by other confounding factors, especially the status of lymph node involvement (data not shown).