Indeed, in GBM, glasdegib (PF-04449913), another SMO inhibitor, is being tested in combination with TMZ in Phase Ib/II in newly diagnosed GBM (recruiting status; NCT03466450), with the rationale that the inhibition of the SHH pathway will interfere with GSCs and endothelial migration, as no preclinical data using this drug in GBM models have been published so far. Here, SMO is linked to glioblastoma.