In vitro, CDK12 loss-of-function mutations and CDK12 inhibition (CDK12i) reduced the expression of HR-related genes, including BRCA1, ATR, and Fanconi-anemia pathway genes, due to premature cleavage and polyadenylation [151,152,153], leading to reduced capacity for HR repair [154,155,156]. The gene discussed is CDK12; the disease is Fanconi anemia.