In view of this, Josephs and colleagues devised a staging system where the earliest TDP-43 pathology seen in the context of AD was in the amygdala (Figure 7a), then the entorhinal cortex and subiculum, and then the dentate gyrus (Figure 7b) or occipitotemporal gyrus (stage III), and then the inferior temporal gyrus (stage IV), and finally the middle frontal gyrus (stage V), of a different pattern and density than typical FTLD-TDP [52]. Here, TARDBP is linked to Alzheimer disease.