Furthermore, they all, apart from MAPT mutations, can usually be diagnosed by the detection of almost exclusively 4-R tau in PSP, CBD and GGT and 3-R tau in PiD, together with the distinctive pathology of astrocytic plaques in CBD, globose neurofibrillary tangles in the basal ganglia and brainstem in PSP, globular glial white matter inclusions in GGT and Pick bodies in PiD. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.