Further evidence of a difference of AD with TDP-43 inclusions from FTLD-TDP was supplied in the work of Tomé et al., who have shown that the type of protein inclusion associated with AD is often different to that associated with FTLD, and furthermore the C terminal species of TDP-43 seen in the AD cases correlated with AD symptoms, whereas the full-length species of TDP-43, when present, correlated more with FTD (frontotemporal dementia) symptoms [54]. Here, TARDBP is linked to Alzheimer disease.