Proteasome inhibitors, arsenic trioxide (ATO), and a CDK4/6 inhibitor palbociclib downregulated FLT3 molecules in FLT3-ITD AML cells by promoting cytotoxic autophagy, inhibiting the expression of FLT3 RNAs, and dysregulating the transcription of FLT3 and PIM1, respectively [119,120,121]. This evidence concerns the gene FLT3 and acute myeloid leukemia.