FLT3 and acute myeloid leukemia: Although the negative prognostic impact of FLT3-ITD might be, at least partially, attenuated by upfront haploidentical stem cell transplantation (haplo-SCT) [125], FLT3 inhibitors remain one of the useful choices for treating the majority of FLT3-mutated AML patients, especially elderly and/or unfit people.