BRAF and cancer: A GC-MS metabolomic study was also performed on a model system of thyrospheres, containing cancer stem-like cells, from B-CPAP and TPC-1 cell lines derived from papillary thyroid cancer of the BRAF-like expression profile class, which showed significant differences in Krebs cycle intermediates, amino acids, cholesterol and fatty acids content when compared to non-cancer stem-like cells [80].