In the particular context of cerebral ischemia, a recent study in male mice showed a decrease in PGRMC1 protein level in the cortical penumbra at day 7 post-MCAO and that inhibition of let-7i miRNA alleviated the ischemia-induced decrease of PGMRC1 expression and increased the beneficial effects of progesterone [86]. The gene discussed is PGRMC1; the disease is brain ischemia.