BRCA2 and breast cancer: In BC, some risk factors are intrinsic: sex and race, as females are more affected than males with a ratio of 70 (black men) and 100 (white men) to 1 woman; age, as its occurrence is higher in women over 50 years of age and in older men; genotype, as some mutations, i.e., involving BRCA1 and BRCA2 are associated with an increased occurrence and worse prognosis.