Given the nature of the alterations which confer a negative prognostic value to LRRK2, i.e., amplifications and deletions, other genes located within or near the locus 12q12 need to be taken into account when trying to explain a putative role of LRRK2 in cancer development, since duplications and deletions can involve large segments of DNA strands. Here, LRRK2 is linked to cancer.