It is also worth noting that the two most commonly encountered mutations of LRRK2 in PD (and therefore pathogenic, albeit in a different setting of human disease), i.e., G2019S and R1441C, are seldom encountered (R1441C: n = 1, G2019S: n = 0, with a case showing a somatic mutation at the same codon: G2019D). Here, LRRK2 is linked to Parkinson disease.