The negative prognostic implications of LRRK2 alterations in the studies analyzed (Figure 4) seem to suggest, on the other hand, that LRRK2 does not simply represent a bystander during the process of cancer pathogenesis; the conflicting results for prostate adenocarcinoma and endometrial carcinoma also seem to indicate a site-specific biological meaning of such alterations. This evidence concerns the gene LRRK2 and cancer.