Identification of the PARK8 locus [1] and mutations in the leucine-rich repeat kinase 2 (LRRK2) gene [2,3], located on chromosome 12 (12q12) in familial cases of Parkinson’s disease (PD), more than fifteen years ago is considered a game-changing discovery in our knowledge of this yet incurable neurodegenerative disorder. Here, LRRK2 is linked to Parkinson disease.