In the present study, we selected both single nucleotide polymorphisms (SNPs) in the MTHFR gene: C677T and A1298C. The aim of this study was to determine their prevalence in cardioembolic stroke due to non-valvular atrial fibrillation and their correlations with cardiovascular risk factors, localization and severity of stroke. Here, MTHFR is linked to cardioembolic stroke.