The comparison between patients with (n = 27) vs. patients without (n = 40) MTHFR A1298C mutation revealed no significant differences between groups regarding age (p = 0.192), BMI (p = 0.194), CHA2DS2-VASC scores (p = 0.534), HASBLED score (p = 0.090), HTN grades (p = 0.173), HF stages (p = 0.070), DBP (p = 0.408), SBP (p = 0.356), HbA1c (p = 0.111), LAV (p = 0.636), LVEDV (0.328), LVEF (p = 0.552), IMT (p = 0.091), hsCRP (p = 0.385) and INR (p = 0.263) (Table 3). This evidence concerns the gene MTHFR and hypertensive disorder.