MTHFR and Stroke: The A1298C MTHFR gene mutation was also analyzed in 70 patients with NVAF and stroke and 70 healthy individuals with no documented episodes of AF matched for age, race and sex by Icli et al. The results of their study suggest that the MTHFR gene A1298C mutation appears not to be associated with non-valvular AF and ischemic stroke in the studied population [21].