Nrf2 gene-specific knockdown studies using Nrf2 null and wild type (WT) mice as a model to Streptococcus pneumoniae-induced pneumonia, identified 53 Nrf2 specific genes and pathways after S. pneumoniae instillation in the lung of WT mice [95], but not in the Nrf2 null mice. This evidence concerns the gene NFE2L2 and pneumonia.